The measured penetration for all 3 PAs was low and compared favourably with existing in vitro data. A single comfrey root formulation was spiked with 3 different congeners (a 7R-monoester, an open-chained 7R-diester, and a cyclic diester) and percutaneous absorption measured per OECD guidelines and good laboratory practices. This study investigated to what extent pyrrolizidine alkaloids are bioavailable following topical exposure, assessing penetration of retronecine-type PAs in an in vitro human skin model. ![]() Current regulatory risk assessment approaches include setting limits that derive from toxicity data coming from the oral route of exposure. Pyrrolizidine alkaloids (PA) are a relevant concern for the safety assessment due to their liver genotoxicity profile, and close attention is paid during manufacturing to minimizing their levels. If you are trying a new product we suggest doing a small patch test.1,2-unsaturated pyrrolizidine alkaloids are found naturally in Symphytum officinale, well known as comfrey, which has a longstanding use for the topical treatment of painful muscle and joint complaints. For internal use always consult your physician or healthcare provider. Our ingredients descriptions are about TOPICAL (external) use ONLY. ![]() This notice is required by the Federal Food, Drug and Cosmetic Act. This information has not been evaluated by the Food and Drug Administration. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. If you have medical concerns regarding yourself or your family you should seek the advice of qualified, licensed health professionals. Do not use the information found on this website to self-diagnose any medical conditions or treat any health problems or diseases. The information provided is not meant to substitute the advice provided by your personal physician or other medical professionals. Please Note: The content and information on this website regarding folklore or health-related benefits of certain ingredients is for educational purposes only and is in no way intended and should not be construed as medical advice to diagnose, treat, cure, or prevent any disease or health condition. Comfrey tea, made from root or leaves, poured over hair as a rinse, makes hair soft as silk. In hair care, comfrey soothes and stimulates the scalp, and enriches lifeless hair. It has mild cleansing properties that make it a good product for removing dirt, oils, and impurities without irritating skin. Comfrey is also great for sensitive skin. Comfrey has mucilage, which is why it is used in skin and hair products for a softening effect.Ĭomfrey leaves or roots in a muslin tea bag added to the bath water can be used to soften skin. Traditionally in Europe, the root, considered nutritive, and cooling was used to help with sprains or strains, or broken bones.Ĭomfrey has gained popularity as a skin-healing herb and is used to heal rashes, inflammation, and other skin problems. The root: The comfrey root contributes more skin-soothing mucilage. Comfrey leaves and roots contain a chemical compound called allantoin which is believed to stimulate cell growth and repair while decreasing inflammation. Native to Europe, it grows in damp, grassy places like river banks and ditches.Īlthough comfrey is no longer recommended for internal use, it is often used in topical salves, ointments, and other skin care products. ![]() Comfrey, Symphytum officinale, is also known by other names like “knitbone” and “bruisewort.” It is a perennial herb with a dark, turnip-like root, thick, hairy stems, and flowers arranged in clusters of purple, blue or white.
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